To help researchers and students make the transition from the classroom and laboratory to research in the `real world,′ the authors reveal the pitfalls and suggest strategies to overcome problems in the design and planning of applied research. With a focus on how to refine research questions as real world events force deviations from the original research plan, they discuss how to study and monitor program implementation and statistical power analysis. They also explore how to assess the human and material resources that will be needed at different times while conducting an applied research design to facilitate the management of data collection, analysis, and interpretation.