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Connections, Cognition and Alzheimer's Disease
105,45 €
+ 210 points
Description
Alzheimer's disease invades the brain from the inside. Unlike an abcess, a metas- tasis or an infarct, the disease follows specific tracks and avoids certain cortical areas while flourishing in others. Any observer is struck by the exquisite selectiv- ity of the lesions and could, indeed, conclude that Alzheimer's disease knows neuroanatomy. However, should the term "disease" be used to define this disor- der? Several genes, located on at least three different chromosomes, have been implicated in the disease. The ApoE4 genotype has been shown to be an impor- tant risk factor, but dementia pugilistica also suggests that environment can be involved in at least some aspects of the disorder. These data favor the now preva- lent view that Alzheimer's disease should instead be considered as a syndrome, and probably all of the contributors to this volume are ready to endorse this point of view. If "Alzheimer's syndrome" is the final common pathway to several pathoge- netic mechanisms, there should be an event at one point in the course of the spe- cific etiology that triggers a somewhat stereotypic diffusion process along some neural connections. Scientists who are fascinated by the way in which the ner- vous system has morphologically encoded its function after a long phylogenetic history are also fascinated by this pathological progression of Alzheimer's syn- drome.
Spécifications
Parties prenantes
- Editeur:
Contenu
- Nombre de pages :
- 194
- Langue:
- Anglais
- Collection :
Caractéristiques
- EAN:
- 9783642645044
- Date de parution :
- 22-09-11
- Format:
- Livre broché
- Format numérique:
- Trade paperback (VS)
- Dimensions :
- 156 mm x 234 mm
- Poids :
- 303 g
