Simulation is a widely used methodology in all the Applied Science disciplines. It provides a flexible, powerful and intuitive tool for investigating how to design a process or system, and how to maximize its efficiency. Simulation's effectiveness depends greatly on how well the simulation experiments are designed and analyzed. Design and Analysis of Simulation Experiments is focused on this crucial phase in the overall process of applying simulation. The book includes the best of both classic and modern methods of simulation experimentation, and as a result, it provides a state-of-the-art treatment of the topic. This book will come to be the standard reference on the topic for both researchers and sophisticated practitioners, and it will be used as a textbook in courses or seminars focusing on this topic.