This textbook is a comprehensive guide to applying design science methodology to solve field problems within and between organizations. Aimed at students, managers, researchers, and professionals in the management sciences, this textbook explores how tacit knowledge can be scientifically extracted and transformed into actionable solution concepts, or artifacts. Key concepts include the co-evolution of problem and design spaces, the development of design propositions, and the creation of practical models, protocols, and policies. The book introduces a new paradigm that balances rigor with relevance, detailing how design propositions can lead to real-world applications. Through its detailed exploration of design science research, the book not only offers tools for immediate problem-solving but also contributes to the broader body of knowledge in management sciences.