•  Retrait gratuit dans votre magasin Club
  •  7.000.000 titres dans notre catalogue
  •  Payer en toute sécurité
  •  Toujours un magasin près de chez vous     
  •  Retrait gratuit dans votre magasin Club
  •  7.000.000 titres dans notre catalogue
  •  Payer en toute sécurité
  •  Toujours un magasin près de chez vous
  1. Accueil
  2. Livres
  3. Sciences humaines
  4. Sciences
  5. Médecine
  6. Formulation Strategies for Dissolution Enhancement of Insoluble Drugs

Formulation Strategies for Dissolution Enhancement of Insoluble Drugs

Dissolution enhancement of challenging drugs which are practically insoluble in gastric fluid and high permeable through stomach

Rajnikant Patel, Madhabhai Patel, Natvarlal M Patel
Livre broché | Anglais
67,45 €
+ 134 points
Livraison sous 1 à 4 semaines
Passer une commande en un clic
Payer en toute sécurité
Livraison en Belgique: 3,99 €
Livraison en magasin gratuite

Description

Dissolution is important parameter to achieve desired concentration of drug in systemic circulation for elicit pharmacological response. The formulation of poorly soluble drugs has been the subjects of much research, as approximately 40% of new chemical entities develop in pharmaceutical industries are insoluble in nature. In the present investigation drugs which are practically insoluble in gastric fluid and having high permeability through stomach were selected. The rational for selecting such type was "Drugs which are only permeable through stomach but due to its solubility limitation in gastric fluid they can not enter in to systemic circulation, further more gastric empting time is ranging form 30 mins to 2 hrs after this time drugs enter in to small intestine where they can soluble but can not permeable through its membrane due to its permeation limitation". To improve dissolution of such drugs in stomach are challenging and rational. Attempts were made to prepare formulations which would dissolved completely within 30 minutes or retain in stomach for more than 2 hrs if drugs can not soluble in 2 hrs even after addition of solubilising enhancing excipients.

Spécifications

Parties prenantes

Auteur(s) :
Editeur:

Contenu

Nombre de pages :
180
Langue:
Anglais

Caractéristiques

EAN:
9783844310696
Date de parution :
10-03-11
Format:
Livre broché
Format numérique:
Trade paperback (VS)
Dimensions :
152 mm x 229 mm
Poids :
272 g

Les avis