This book explores the development of a model to predict and explain the degree of success it is possible to achieve in implementing e-health systems. It is aimed at practising professionals and students in all areas of medical informatics, hospital administration, and health care. The model developed here allows an institution to benchmark its progress towards IHCS implementation and advises administrators where to invest resources to increase the chance of successful implementation. A set of case studies highlights key features of the model. Each study describes an attempt by an organization to implement the Comprehensive Health Enhancement Support System (CHESS), a proven IHCS. After examining the success or failure of each implementation, the book suggests steps that could have been taken to address weaknesses identified by the model.