A class of pseudodifferential operators on the Heisenberg group is defined. As it should be, this class is an algebra containing the class of differential operators. Furthermore, those pseudodifferential operators act continuously on Sobolev spaces and the loss of derivatives may be controled by the order of the operator. Although a large number of works have been devoted in the past to the construction and the study of algebras of variable-coefficient operators, including some very interesting works on the Heisenberg group, our approach is different, and in particular puts into light microlocal directions and completes, with the Littlewood-Paley theory initiated in 2000 by Bahouri, Gérard and Xu, a microlocal analysis of the Heisenberg group.