Description

The objective of the research work was to design novel proniosomes containing highly potent drug tretinoin. In this research work, proniosomes have been prepared by all the three known methods which are COACERVATION PHASE SEPARATION METHOD, SLURRY METHOD and third SLOW SPRAY COATING METHOD. In first method that is coacervation phase separation method the amount of cholesterol and phospholipids were kept constant but the different surfactants are used in varying ratios which has effect on drug entrapment, vesicle size and entrapment efficiency of prepared proniosomes. The proniosome formulation F7 showed highest in vitro drug release and controlled drug release pattern. Small multilamellar vesicles, with sizes ranging from about 100 to 200 nm, were successfully obtained in SEM. Results indicated a significant influence of different surfactant amounts on proniosome size and encapsulation efficiency.