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  7. Sample Size Calculations in Clinical Research

Sample Size Calculations in Clinical Research

Shein-Chung Chow, Jun Shao, Hansheng Wang
Livre relié | Anglais | Chapman & Hall/CRC Biostatistics
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Description

Praise for the Second Edition:

"... this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study."

 -Biometrics

"This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered ..." - Journal of the Royal Statistical Society

Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation.

Features:

  • Compares the relative merits and disadvantages of statistical methods for sample size calculations

  • Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages

  • Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women's health

  • Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches

    • This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.

    　

    Spécifications

    Parties prenantes

    Auteur(s) :
    Shein-Chung ChowJun ShaoHansheng Wang
    Editeur:
    CRC Press

    Contenu

    Nombre de pages :
    510
    Langue:
    Anglais
    Collection :
    Chapman & Hall/CRC Biostatistics

    Caractéristiques

    EAN:
    9781138740983
    Date de parution :
    30-08-17
    Format:
    Livre relié
    Format numérique:
    Genaaid
    Dimensions :
    178 mm x 257 mm
    Poids :
    1133 g

    Les avis