Rick is working as a lab technician when his co-workers decide to play a little practical joke on him. While he is out in the men's room, one of the senior lab technicians switches the fluid in his drink for the fluid he has been working on that gives a person superpowers.
Meanwhile, at Rick's apartment his roommates, Nikita and Dolly are discussing their sexual bucket lists. Each one has some items that they can tick off with each other and decide to include Rick in a threesome.
On Friday, both Nikita and Dolly decide to surprise Nick when he gets home from work by starting their threesome early in his bed. One delightfully naughty and explicit encounter later, and both Dolly and Nikita discover that Rick's love juice has given them superpowers.
Meanwhile, Rick's co-workers Daphne and Jimmy are exploring their new superpowers. Daphne has the power to seduce any man or woman, while Jimmy's love juice makes body parts grow larger.
The Order of Vile Villany has discovered what is occurring and makes Jimmy an offer that he cannot refuse. Join and get a full benefits package including health care and a 401K plus three starter minions as a Level 1 Nefarious.
On the other side of town, Daphne's former boyfriend Rodney plots to get her back using the superpower she gave him regarding the creation of special lust bolts for his crossbow. Sultry Superheroes as only Pearl can do them.