Foreword
Preface
Chapter 1
Resistance to Targeted Therapies As a Result of Mutation(s) in the Target
Alexis B. Cortot and Pasi A. Jänne
Chapter 2
The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies
Daniel G. Gioeli
Chapter 3
Cancer Signaling Network Analysis by Quantitative Mass Spectrometry
Jason R. Neil and Forest M. White
Chapter 4
Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications
Julia D. Wulfkuhle, Menawar Khalil, Joseph C. Watson, Lance A. Liotta, and Emanuel F. Petricoin III
Chapter 5
Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies
Omar D. Perez
Chapter 6
Mathematical and Computational Models in Cancer
Sudhir Chowbina, Kevin Janes, Shayn M. Peirce, and Jason Papin
Chapter 7
Somatic Evolution of Acquired Drug Resistance in Cancer
John W. Pepper
Chapter 8
Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer
Edward Gunther
Chapter 9
MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways
Benjamin Kefas and Benjamin W. Purow
Chapter 10
Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance
Yun Dai and Steven Grant