Three nephews and three eccentric uncles.
It's 2050 and Robbie Elders has all but forgotten about his oddball, religious fanatic uncle, tim tim. He's taken up the latest fad, genealogical research based solely on DNA. But Robbie's "inconclusive" DNA results are unsettling. He crashes back to his childhood, back to his world of comic books and tim tim.
"I opt for posh and London" declares Lady Florence Stour. It's 2019 and time for a Royal Wedding. Robbie's uncle, Stef, is engaged to Lady Florence, a distant member of the British royal family. Stef's Baltimore clan have been invited, but Robbie's mom and dad can't attend. They've entrusted Robbie and big brother, Doyle, to their mom's two eccentric brothers, uncles Roy and Roland. Roy, a weathered waterman with a severe Baltimore accent, lives for Maryland blue crabs. Roland, a mildly hypochondriacal actor, lives to survive the Karens he unavoidably encounters. And then there's Desales, Roy's smart aleck, teenage son. He lives to prank. They've descended upon London. What could possibly go wrong?
Meanwhile, tim tim has been coaching Robbie on "the mission." A silly religious fantasy according to Robbie's atheist parents and the therapists. Or perhaps not? Things are not always as they appear in The Big Comb Over.