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1, 3, 4-Oxadiazole analogues

Synthesis and pharmacological evaluation

Radhika Maheshwari, Pooja Chawla, Shubhini Saraf
Livre broché | Anglais
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Description

Heterocyclic compounds have been well researched and still continue to provide solutions to innumerable problems faced by mankind. One of such problems is increasing resistance of microbes against existing antibiotics. Often, infection is found to be associated with inflammation. 1, 3, 4-oxadiazoles have been explored by a number of scientists worldwide these derivatives have emerged as potential lead molecules for development of newer antimicrobial and anti-inflammatory agents. The present work reports the synthesis and evaluation of some 2, 5-disubstituted 1, 3, 4-oxadiazoles and their pharmacological evaluation for antimicrobial, analgesic and anti-inflammatory activities. A fair number of compounds were found to have good anti-inflammatory activity in carrageenan-induced rat paw oedema test, while all the compounds showed significant antibacterial activity. The contents of this book must make an excellent read for those interested in heterocyclic research.

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Contenu

Nombre de pages :
108
Langue:
Anglais

Caractéristiques

EAN:
9783659162978
Date de parution :
12-07-12
Format:
Livre broché
Format numérique:
Trade paperback (VS)
Dimensions :
152 mm x 229 mm
Poids :
167 g

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