A vast literature exists dealing with trace metals and a number of outstanding monographs deal with the biological, biochemical, or clinical effects of a specific trace metal or trace metals in general. However, newer aspects of trace metal research, i.e. the developmental aspects and generic implications, have not been systematically discussed in any existing texts. The present two volumes will summarize the present status of research in these areas and serve as milestones for future development in these areas of trace metal research.