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Molecular Characterization of Tgf Mediated Cancer Cell Proliferation
TGF Switch in Cancer
Garima Singh, Shiv Kishor Singh, Volker Ellenrieder
Livre broché | Anglais
48,45 €
+ 96 points
Description
TGFβ has a dual role in carcinogenesis, acting as a growth inhibitor in early tumor stages and a promoter of cell proliferation in advanced diseases. Although this cellular phenomenon is well established, the underlying molecular mechanisms remain elusive. Here, we report that sequential induction of NFAT and c-Myc transcription factors is sufficient and required for the TGFβ switch from a cell cycle inhibitor to a growth promoter pathway in cancer cells. TGFβ induces the expression and activation of NFAT factors, which then translocate into the nucleus to promote c-Myc expression. In response to TGFβ, activated NFAT factors bind to and displace Smad3 repressor complexes from the c-Myc promoter. c-Myc in turn stimulates cell cycle progression and growth through up-regulation of D-type cyclins. Most importantly, NFAT knockdown not only prevents c-Myc activation and cell proliferation, but also partially restores TGF-beta-induced cell cycle arrest and growth suppression. Taken together, this study provides the first evidence for a Smad-independent master regulatory pathway in TGFβ-promoted cell growth that is defined by sequential transcriptional activation of NFAT and c-Myc factors.
Spécifications
Parties prenantes
- Auteur(s) :
- Editeur:
Contenu
- Nombre de pages :
- 100
- Langue:
- Anglais
Caractéristiques
- EAN:
- 9783639298017
- Date de parution :
- 04-11-10
- Format:
- Livre broché
- Format numérique:
- Trade paperback (VS)
- Dimensions :
- 152 mm x 229 mm
- Poids :
- 158 g
