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Normal and Binding Mode Analysis of Breast Cancer Resistance Protein
Structural Bioinformatics of BCRP
Prasanth Kumar, Saumya Patel, Himanshu Pandya
Livre broché | Anglais
48,45 €
+ 96 points
Description
Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.
Spécifications
Parties prenantes
- Auteur(s) :
- Editeur:
Contenu
- Nombre de pages :
- 104
- Langue:
- Anglais
Caractéristiques
- EAN:
- 9783659153129
- Date de parution :
- 09-06-12
- Format:
- Livre broché
- Format numérique:
- Trade paperback (VS)
- Dimensions :
- 152 mm x 229 mm
- Poids :
- 163 g
