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  6. Statistical Design and Analysis of Clinical Trials

Statistical Design and Analysis of Clinical Trials

Principles and Methods

Weichung Joe Shih
Livre relié | Anglais | Chapman & Hall/CRC Biostatistics
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Description

Statistical Design and Analysis of Clinical Trials: Principles and Methods concentrates on the biostatistics component of clinical trials. Developed from the authors' courses taught to public health and medical students, residents, and fellows during the past 15 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods.

Teach Your Students How to Design, Monitor, and Analyze Clinical Trials

The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, explain the concept of different missing data processes, and describe how to analyze incomplete data by proper multiple imputations.

Turn Your Students into Better Clinical Trial Investigators

This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students a multidisciplinary understanding of the concepts and techniques involved in designing and analyzing various types of trials. The book's balanced set of homework assignments and in-class exercises are appropriate for students in (bio)statistics, epidemiology, medicine, pharmacy, and public health.

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Parties prenantes

Auteur(s) :
Editeur:

Contenu

Nombre de pages :
244
Langue:
Anglais
Collection :

Caractéristiques

EAN:
9781482250497
Date de parution :
23-07-15
Format:
Livre relié
Format numérique:
Genaaid
Dimensions :
155 mm x 236 mm
Poids :
476 g

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