This book focuses on how digital technologies and rapid developments in artificial intelligence are shaping a new generation of cyber-physical systems based on the convergence among robots, sensors, and 3D printing. The book tells a story based on data and indicators to compare the resilience to this transformation in some key manufacturing regions. As a specific case study, the book discusses in length the transformation of the manufacturing processes in the Italian automotive industry. The authors conclude the book by providing policy implications for regions and cities.