This edited volume explores key challenges facing Vietnamese universities amidst digital transformation, navigating the intersection of technology and cultural values, competition, and open education. Chapters in this book offer insights into the current landscape of Vietnamese higher education, outlining strategies for institutional success and preparing students for post-graduation careers. Covering topics such as new teaching and research trends, online learning, course development practices, and support mechanisms for student success, this book provides essential guidance for both public and private universities. It emphasizes strategies to enhance student outcomes within degree programs and optimize the effectiveness of online courses.