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Description
erebellar ataxia is a failure in muscular coordination that re- C sults from a slow, progressive deterioration of neurons in the cerebellum. An estimated 150,000 people are affected by the he- reditary ataxias and related disorders in the United States. At present, there is no known cure. In an experimental treatment aimed at reconstructing the damaged pathway through exog- enous neuronal supplementation, genetically ataxic mice have been used for intracerebral grafting of genetically healthy cerebellar neuroblasts, and evidence has been obtained for graft-induced en- hancement of behavioral responses after bilateral cerebellar grafts. Such results are encouraging and underscore the potential of the neural grafting technique in restoring cerebellar function. How- ever, many of the pathological and biochemical mechanisms in the interaction between grafted tissue and the host brain need to be further elucidated in extensive experimental studies, and great cau- tion must be used in contemplating the theoretical feasibility of a possible application in humans.
Spécifications
Parties prenantes
- Auteur(s) :
- Editeur:
Contenu
- Nombre de pages :
- 162
- Langue:
- Anglais
- Collection :
Caractéristiques
- EAN:
- 9783662222157
- Date de parution :
- 20-11-13
- Format:
- Livre broché
- Format numérique:
- Trade paperback (VS)
- Dimensions :
- 178 mm x 254 mm
- Poids :
- 317 g
